Assessment of Chronic Kidney Disease in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD); A Single Center Experience

 Mona Mohammed Abdelrahman1*, Shimaa Badawy Hemdan2, Mohamed Ezeldin 3, Osama Abbas Orabi 4, Shimaa Anwar Rashed5, Ahmed Nagah Nour Eldin 4

  1. Lecturer of Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Egypt. ORCID: 0000-0002-8784-848X
  2. Lecturer of Medical Biochemistry Department, Faculty of Medicine, Sohag University, Egypt.
  3. Lecturer of Diagnostic and Interventional Radiology Department, Faculty of Medicine, Sohag University, Egypt. ORCID: 0000-0001-5613-1729.
  4.  Lecturer of Internal Medicine Department, Faculty of Medicine, Sohag University, Egypt.
  5. Clinical and Chemical Pathology Department, Faculty of Medicine, Sohag University, Egypt.

*Corresponding author: Mona Mohammed Abdelrahman, Tropical medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Egypt. Postal code: 82524. Telephone: 00201021025895, Email: monamohamed@med.sohag.edu.eg. ORCID: 0000-0002-8784-848X.

·         Running title: chronic kidney disease in NAFLD.

DOI: 10.21608/ajgh.2023.178105.1022.

Type of manuscript: original research.

Date of submission: 01- December 2022.

Revised: 01-January- 2022.

Accepted: 6- January -2023.

First online:7 - January -2023.

 

Abstract:

Background:

Non-alcoholic fatty liver disease (NAFLD) represents a considerable percentage of chronic liver diseases worldwide. The liver is not the only organ affected by NAFLD but also affects other organs such as the cardiovascular system and the kidney. In recent decades, there has been a growing body of evidence linking NAFLD to kidney function. So, the current study aims to assess the percentage of chronic kidney disease (CKD) in NAFLD patients and its link to different stages of hepatic fibrosis.

 

Patients and Methods: A case-control study evaluated 62 non-alcoholic fatty liver disease patients and a control group of 38 volunteers with apparently healthy livers (normal echo pattern by ultrasound). All participants underwent serum creatinine measurement, albumin creatinine ratio in urine, calculation of estimated glomerular filtration rate (eGFR), abdominal ultrasound, and fibroScan examination.

Results: The authors showed that the percentage of patients with chronic kidney diseases (patients with GFR less than 60 ml or micro-albuminuria) were significantly higher among NAFLD groups than in healthy controls. There was a significant positive correlation between the albumin creatinine ratio and subcutaneous fat thickness, BMI, and steatosis degrees. The estimated glomerular filtration rate (eGFR) and the age of the patients had a significant negative correlation. In comparison, the eGFR and AST levels had a significant positive correlation.

Conclusions: Our results showed that NAFLD substantially raises the risk of getting CKD.

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