Effectiveness of G-EYE colonoscopy compared with Standard Colonoscopy in Colorectal Polyps detection: A Tandem Colonoscopy Study in an Egyptian Population

 

Authors Ahmed Elshafie 1 Ehab Nashaat 2 Ayman Mohamed Abdel Aziz 3 Abdallah Shehatah El-Sayed 4 Kareem Ahmed Abdelnabi 4 1 Department of Internal Medicine, Hepatology and Gastroenterology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 2 MD of internal medicine, Professor of internal medicine, Hepatology and GIT, Faculty of Medicine, Ain Shams University 3 Department of Hepato-gastroenterology, Theodor Bilharz Research Institute, Cairo, Egypt. Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, October 6 University. 4 Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 10.21608/ajgh.2026.462248.1095 Abstract Background: Colorectal carcinoma (CRC) is one of the most common malignancies globally. It usually arises from adenomatous polyps 10–15 years before its development. Screening colonoscopy and polypectomy help prevent CRC. In a standard colonoscopy, 22–26% of adenomas were missed. This led to an increase in interval CRCs, underscoring the need for improved detection technologies, such as the G-EYE balloon system. Aim: This work aimed to compare polyp and adenoma detection rates between standard colonoscopy and G-EYE balloon-assisted colonoscopy within the Egyptian population. Secondary aims were assessment of polyp/adenoma characteristics, missed adenoma detection, and procedure safety. Patients and Methods: This was a prospective, single-masked, back-to-back tandem study. Eighty patients were included in this study and were scheduled for colonoscopy. All patients underwent standard colonoscopy, followed by G-EYE colonoscopy, using identical high-definition scopes under sedation. Polyps were documented during the first pass, removed thereafter, and histopathologically classified. Results: Eleven patients were excluded, and 69 patients underwent both standard colonoscopy (SC) and G-EYE colonoscopy. G-EYE colonoscopy significantly outperformed standard colonoscopy in polyp detection rate (PDR) (40.6% vs. 21.7%, p = .027), adenoma detection rate (ADR) (28.99% vs. 21.7%, p = .039), and mean polyp detection per patient (0.62 vs. 0.28, p = .002), detecting 43 vs. 19 polyps (including more diminutive lesions, p = .049). The standard colonoscopy adenoma miss rate was 52.2%, mostly of diminutive and small sizes. Conclusion: G-EYE balloon colonoscopy increases polyp and adenoma detection and reduces missed adenomas in the Egyptian population. It presents a safe, efficient tool for CRC prevention. Highlights G-EYE balloon-assisted colonoscopy significantly improves Polyp Detection Rate (PDR) compared to standard methods. In an Egyptian population study, G-EYE increased PDR from 21.7% to 40.6%. Adenoma Detection Rate (ADR) increased significantly (p=0.012) with the G-EYE system. The technology proves effective in high-volume clinical settings aimed at improving colorectal cancer prevention.